TMP CLassics: Around the world in 80 Plagues: The Elephantiasis in the room

March 27, 2021 Joshua Dworetzky

In this episode, Dr's J and Santhosh cover the tropical infection of filarial elephantiasis. Along the way, they discuss Jules Verne, the Ebers Papyrus, Greek Mythology and Skiapodes, how not to order Greek Coffee, St Thomas' curse, Nematodes and Lovecraft, worm transmission and mating, hydrocele, lymphatic expansion, chyluria, parascientists, Mosquit watches, night blood diagnosis, Loa and voodoo, symptoms of filarial infection, treatment of infection, Nick at Night, worm neural paralyzers, prevention of infestation, and podoconiasis. So sit back and prepare to learn about elephantiasis, the disease you'll never forget!

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722: Pandemic Journal Club- All Good Things

March 20, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh round up whats new in the world of pandemic medicine in everyone’s favorite biweekly segment. Along the way, they cover cancel culture, astrazeneca, johnson and johnson, v-mail, vaccine efficacy statistics, tommy tutone, asymptomatic transmission, vaccines in pregnancy, a anti covid pill and more! So Sit back and relax as we tell you what’s new in the world of medicine!

Sources
1) https://jamanetwork.com/journals/jama/fullarticle/2777172
2) https://www.medscape.com/viewarticle/947376?src=mkm_covid_update_210312_MSCPEDIT&uac=263012FR&impID=3245883&faf=1
3) https://www.medscape.com/viewarticle/947289?src=mkm_covid_update_210312_MSCPEDIT&uac=263012FR&impID=3245883&faf=1
4) https://www.medscape.com/viewarticle/947211

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721: Prehistoric Medicine: Neanderthal that and a bag of genes

March 13, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh discuss the surprising medical contributions from our caveman cousins. Along the way they cover the flintstones, medical etymology, viral history, caveman genes, ancient infections being unearthed, intro genetics, adaptive evolution, neanderthal skin types, HLA and TLR, denisovans, human sexual skill, herv-K and more! So sit back and relax as we teach you about genetic protections

Sources
1) https://www.nature.com/articles/d41586-018-06004-0
2) https://www.nature.com/articles/s41586-020-2818-3
3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23960/
4)https://www.sciencealert.com/neanderthal-rna-virus-protein-genes-benefit-modern-humans
5)https://www.weforum.org/agenda/2017/05/the-deadly-diseases-being-released-by-climate-change/
6)https://www.cell.com/cell/pdf/S0092-8674(18)31095-X.pdf

720 Women's Medical History Month

March 6, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh talk about famous female physicians and scientists. Along the way, they cover ancient Egyptian surgery, Metrodora, hidden textsbooks, STEM awards, Dr Helen Taussig, tetralogy of Fallot, pediatric puns, patent ductus arteriosus, thalidomide, Dr Gertrude Elion, rational drug design and more! So sit back and relax as we teach you about some medical women who changed the world!

Sources
1) ttps://cfmedicine.nlm.nih.gov/physicians/biography_316.html
2) https://www.jusurgery.com/universalsurgery/aspasia-and-cleopatra-metrodora-twomajestic-female-physician--surgeons-in-theearly-byzantine-era.php?aid=11083
3) https://www.nobelprize.org/prizes/medicine/1988/elion/biographical/

719 Black Medical History Month

February 27, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh talk about notable black medical achievments in history. Along the way, they cover the black panthers, free clinics, national screening programs, scrooge mcduck, statistical rap battles, James Mcune Smith, ptyalism, henrietta lacks, informed consent, and a special aside about the mars perseverance landing! SO SIt back and relax as we share exciting infor about black medical achievements

SOurces
1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024359/
2) https://manifold.umn.edu/read/body-and-soul/section/029716dd-0f4a-410b-ab67-d4bbd799b55c3) https://journals.physiology.org/doi/full/10.1152/advan.00119.2018#:~:text=1)%20was%20the%20first%20African,York%20City%20Colored%20Orphan%20Asylum.
3)https://sitn.hms.harvard.edu/flash/2020/vessels-for-collective-progress-the-use-of-hela-cells-in-covid-19-research/

718 Journal CLub- The World of Tomorrow

February 20, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh once again review the latest in medical news in everyone favorite segment, journal club, this time with an emphasis on future discoviers. Along the way they cover aroma diagnosing and deep nose, smellovision, human yarn, the luke hand, robokinesis, the lazarus phenomeon and more! So sit back and relax as we teach you whats new in the world of medicine

Sources
1)https://nautil.us/issue/95/escape/the-doctor-will-sniff-you-now
2) https://www.newscientist.com/article/2232357-yarn-grown-from-human-skin-cells-could-be-knitted-into-your-body/
3) https://www.jhuapl.edu/PressRelease/191016
4) https://www.hindawi.com/journals/crim/2015/724174/

717: Surprising Origins

February 13, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh discuss common objects and ideas you may not realize were connected to disease. Along the way they cover old timey radiators, terrifying powerpoints, the fresh air movement, open air schools, influential John Hopkins female graduates and snuggies, Japanese school design, the evolution of bathrooms, chamberpots and bathroom attendants, linoleum, powder rooms, crash test dummies and more! So Sit back and relax as we reveal the surprising medical connections of everyday objects

Sources
1) https://www.ebs.nyc/post/1918-flu-impacts-the-heating-and-ventilation-industry
2) https://www.history.com/news/school-outside-tuberculosis
3)https://www.chicagotribune.com/history/ct-opinion-flashback-open-air-schools-tuberculosis-20200501-phyphmoe4vhhnelpjj2sck7fmi-story.html
4) https://www.bloomberg.com/news/articles/2020-04-10/the-war-against-coronavirus-comes-to-the-bathroom
5)https://www.messynessychic.com/2019/12/17/the-curious-career-of-being-a-human-crash-test-dummy/

716: Journal Club- Mostly Simply Science

February 6, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh once again round up the latest medical research in everyone’s favorite bimonthly segment. Along the way they cover Dr J’s bad segues, Covid and cholesterol, boy bands and syncytium, new covid treatments, spanish sea squirts, new applications for cancer drugs, covid variants, canabidiol as a new antibiotic class, drug resistant infections, zombie cells and more! So sit back and relax as we cover whats new in the world of medicine!

Sources
1) SARS-CoV-2 needs cholesterol to invade cells and form mega cells (phys.org)
2) https://observer.com/2021/01/aplidin-covid-drug-cancer-treatment/
3) https://www.nature.com/articles/s42003-020-01530-y
4) https://www.healthline.com/health-news/anti-aging-treatment-that-kills-zombie-cells

715 The Scoop on Poop

January 30, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh, with pharmacist Eleanor discuss all things fecal, scatalogical, and excremental from the earth to the moon. Along the way, they cover quaker pharmacists, Lewis and Clark’s medical supplies, scatalogical cartography, organic mercury, poop on the moon, bacteria in space, the bristol stool scale, different poo smells, diaper rash, how often you should normally poop, a japanese video game, and more! So Sit back and relax as we shoot the shit on poop facts!

Sources
1)http://www.sarahalbeebooks.com/2012/01/the-poop-on-lewis-and-clark/
2)http://www.lewis-clark.org/article/2561
3)http://www.lewis-clark.org/article/2562
4)https://io9.gizmodo.com/archaeologists-tracked-lewis-and-clark-by-following-the-1727887223
5) https://kotaku.com/a-poop-based-game-released-in-japan-to-save-lives-1845704375

TMP Classics: The Hot Zone- Biocontainment with Dr Hewlett

January 23, 2021 Joshua Dworetzky

In this episode, Dr's J and Santhosh learn about the treatment and handling of highly infectious agents with special guest Dr Hewlett, medical director of the Nebraska Biocontainment Unit. Along the way, they cover what is biocontainment, designing a containment room, Level 4 laboratories, worst case scenarios, surprise toilet dangers, patient bonding and combatting boredom in isolation, unique challenges of the unit, managing disease with no good treatment, and more! So sit back as we try to contain our excitement over this interview!

Sources
1) National Ebola Traing and Education Center NETEC.org
2) https://www.nebraskamed.com/biocontainment

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714: Journal Club- Bad Segues, Good Science

January 16, 2021 Joshua Dworetzky

In this episode Dr’s J and Santhosh return to everyones favorite alternate week segment, journal club, this time with a grab bag of stories from around the world. Along the way, they cover bear puns, salivary antibiotics, microbiomes, hibernating cells, tumor compositions, cancer vaccines, immunotherapy, phase 1 trials, aminoglycosides, a side effect prevented, bacterial hard drives, infectious texting and more! So sit back and relax as we tell you whats new in the world of medicine!

Sources
https://www.zmescience.com/science/brown-bear-straph-saliva-8255362/
https://newatlas.com/medical/cancer-cells-dormant-hibernate-diapause-chemotherapy/
https://www.livescience.com/62161-cancer-vaccine-trial.html
https://stanmed.stanford.edu/listening/scientists-seek-improve-popular-antibiotic-that-causes-deafness.html
https://www.newscientist.com/article/2264383-crispr-gene-editing-used-to-store-data-in-dna-inside-living-cells/

713: Around the World in 80 Plagues- I eat, Ergot, I'm sick

January 10, 2021 Joshua Dworetzky

In this episode, Dr’s J and Santhosh discuss ergotism, covering it’s surprising journey from disease to drug. Along the way, they cover medieval art history, Saint Anthony, the antonites, uses for amputated limbs, medieval locums doctors, plant smut, gangrenous ergotism, european history influence, epidemiology, potatoes to the rescue, nanny goats, pulvis ad partem, migraine treatment and more! So sit back and relax as we teach you all about a fungus among us!

Sources
1) https://asm.org/Articles/2018/November/From-Poisoning-to-Pharmacy-A-Tale-of-Two-Ergots
2) https://www.apsnet.org/edcenter/disandpath/fungalasco/pdlessons/Pages/Ergot.aspx
3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343691/

712- The Vacci-Nation: Moderna Love, I only have Pfizer you

January 2, 2021 Joshua Dworetzky

In this double dose episode, Dr’s J and Santhosh, joined by friend of the show Pharmacist Eleanor cover the ins, out, and faq’s about the covid vaccines. Along the way, they cover the Offspring, the speed of development, messenger RNA, nanoparticles, women in science, vaccine delivery logistics, slow covid inflammation, RNA interactions with DNA, length of activity, facts and figures, pfizer v moderna comparison, side effect profiles, vaccine brand names, the immune system, vaccine ingredients, allergies, hiv and more! SO Sit back and relax as we answer all your questions on the latest vaccine update!

Sources
1) https://coronavirus.medium.com/decoding-modernas-covid-19-vaccine-ingredients-23ea87c5f234?gi=sd
2) )https://www.nature.com/articles/d41587-020-00022-y
3)https://jamanetwork.com/journals/jama/fullarticle/2770485
4) https://www.statnews.com/2020/12/19/a-side-by-side-comparison-of-the-pfizer-biontech-and-moderna-vaccines
5) https://www.fda.gov/media/144412/download

711- What the Dickens? A Holiday Special

December 26, 2020 Joshua Dworetzky

Merry Xmas, Happy Hanukkah and Joyous Holidays dear listeners. In this years holiday episode, Dr’s J and Santhosh and Ward have a spirited debate on the differential diagnosis of Ebenezer Scrooge. Along the way, they cover covid groundhougs, creating a differential with acronyms, bob marley, food poisoning, ergotamines, apoplexy, phineas gage, seizures, concussions, parkinsons and more! So Sit back and relax as we give you a whole new view of a holiday antihero!

710 A history of Aspirin

December 19, 2020 Joshua Dworetzky

In this episode, Dr’s J and Santhosh discuss the history of one of our oldest drugs, with the help of friend of the show Pharmacist Eleanor. Along the way, they cover ancient greece, botany puns, ye olde english recipes, pharmacist scruples, german chemists, medical chewing gum, aspirin side effects, fun with measurement, and more! So sit back, take two cohostos, and call us in the morning!

Sources
1) https://www.pharmaceutical-journal.com/news-and-analysis/infographics/a-history-of-aspirin/20066661.article?firstPass=false
2)https://www.nlm.nih.gov/hmd/greek/greek_dioscorides.html
3)http://www.cancerlynx.com/BOOKONEAROMATICS.PDF
4)https://worldneurologyonline.com/article/controversial-story-aspirin/

TMP Holiday Classics: The 12 Days of Xmas- 2 Docs Diagnosing

December 12, 2020 Joshua Dworetzky

Please enjoy this classic holiday episode as Dr J dislocated his arm this week and was unable to edit. We’ll be back soon with all new episodes!

In this episode, Dr’s J and Santhosh break down medical conditions from a popular Christmas carol. Along the way, they discuss what exactly are the 12 days of Christmas, the dangers of over-gifting birds, tubirdculosis, the Audubon xmas count, milkmaid skin, what made those lords and ladies dance, the tarantella, and more! Bonus: a rebuttal to the opponents of Baby it’s cold outside. So sit back, relax, and sing along as we gift the inspiration behind this series to you!

709 Journal Club- Pandemic Updates

December 5, 2020 Joshua Dworetzky

In this episode, Dr’s J, Santhosh, and Ward once again round up whats new in medical news, with an emphasis on developing covid updates. Along the way, they cover Dr Wards new podcast, vaccine one-upsmanship, phase 3 trial protocols, sloppy science, trial conduction pitfalls, comparison of methods amongst the upcoming vaccines, what causes the loss of smell and taste in covid, sustentacular cells, nose training studies, how long natural immunity vs vaccine induced immunity could last, and more! So Sit back and relax as we bring you the latest on whats new in the world of pandemic medicine!

Sources
1) https://www.wired.com/story/the-astrazeneca-covid-vaccine-data-isnt-up-to-snuff/
2) https://www.livescience.com/covid-10-smell-loss-explained.html
3) https://www.livescience.com/coronavirus-immunity-long-lasting.html
4) https://www.livescience.com/26124-coca-cola-stomach-blockages.html

708 Civil War Medicine

November 28, 2020 Joshua Dworetzky

In this episode, Dr’s J and Santhosh cover civil war medicine. Along the way, they cover Dr Santhosh difficulty with historical dates, foundational modern medicine, Surgeon General William Hammond, case study museums, battle triage, lewis and clark, the dangers of advancing medical knowledge, spontaneous combustion, early anesthesia and ultrasounds, confederate herbalist pharmacy, biofilms and quorum sensing, artificial limbs and more! So sit back and relax as we teach you the medical views of the grey and the blue!

Sources
1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487437/
2) https://www.zmescience.com/science/plants-civil-war-bacteria-253653535/
3) https://pubmed.ncbi.nlm.nih.gov/3046560/
4)https://pubmed.ncbi.nlm.nih.gov/14507123/
5) https://www.facebook.com/watch/?v=3249030981856097

707 Journal Club- A New Hope

November 21, 2020 Joshua Dworetzky

In this episode, Dr’s J and Santhosh once again perform their bimonthly roundup of recent papers in the medical world. Along the way, they cover pandemic updates like a new treatment bamnlanivimab, classic rock and pop music drug references, emergency use authorizations, a listener challenge, pfizer vaccine efficacy data, flu season, new cortisol testing, ethnic earwax differences, overactive brain research and more! SO sit back and relax as we cover what’s new in the world of medicine!

Sources
1) https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibody-treatment-covid-19
2) https://blogs.sciencemag.org/pipeline/archives/2020/11/09/vaccine-efficacy-data
3) https://www.livescience.com/earwax-reveals-stress-anxiety.html
4) https://www.sciencedirect.com/science/article/pii/S0010945220303130?via%3Dihub
5) https://www.sciencemag.org/news/2019/10/new-drug-forces-flu-virus-error-catastrophe-overwhelming-it-mutations

706 Around the World in 80 Plagues- Lights, Camera, Actinomyces

November 14, 2020 Joshua Dworetzky

In this episode, Dr’s J and Santhosh cover the bacteria actinomyces and its associated diseases. Along the way, they cover infected Egyptian murals, carmen sandiego, lumpy bumpy jaw, anaerobic bacteria, medical etymology, disrespectful bacteria, unique properties of bully bacteria, antibiotic contributions, bacterial colonization, actinomycosis, insidious infections, sulfur granules, diagnosis, treatment and the possible return of just the tip! So sit back and relax as as we dive into a lesser known bacteria and dish the dirt on actinomyces!

Sources
1) https://cmr.asm.org/content/28/2/419
2) https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/actinomycosis-3/#:~:text=Actinomycosis%20is%20often%20called%20the%20%E2%80%9Cgreat%20masquerader%E2%80%9D%20of,fever%2C%20anorexia%2C%20malaise%2C%20weight%20loss%2C%20and%20night%20sweats.
3) https://www.sciencedirect.com/science/article/pii/S0944501318308267
4) https://www.smithsonianmag.com/travel/how-bacteria-make-underground-cave-shine-gold-and-why-nasa-wants-study-them-180955670/